Combination antibiotic testing – 2 are better than 1
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Antibiotic combination testing
Combination antibiotic therapy is used mainly in critically ill patients due to widespread emergence of multidrug resistance organisms (MDR) and increasing resistance to last resort antibiotics. Combination therapy has potential advantage as the second drug may enhance the activity of the first or may inhibit the activity of a resistance mechanism. The test provides minimum inhibitory concentration (MIC) result for newer antibiotic combinations like Ceftazidime-avibactam and Aztreonam-avibactam using Broth microdilution method (BMD). These combinations are helpful for patients with bugs resistant to meropenem and colistin.
Biofilm screening assay for antimicrobial therapy
Biofilm infections are difficult to clinically manage. Standard antibiotics will not clear biofilm mediated infections in humans due to its poor penetration. Accordingly, we will test appropriate antibiotics with MIC levels for biofilms for patients with devices, nosocomial infections, persistent infections, prosthetic infections. This helps in tailoring the treatment with increased dose or antibiotic combinations in these patients.